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Rabbit Anti-SEC23A Recombinant Antibody (CBXS-1349) (CBMAB-S4207-CQ)

This product is a rabbit antibody that recognizes SEC23A. The antibody CBXS-1349 can be used for immunoassay techniques such as: WB, FC.
See all SEC23A antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1349
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sec23 homolog A, coat complex II component
Introduction
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.
Entrez Gene ID
10484
UniProt ID
Q15436
Alternative Names
CLSD; hSec23A
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane (By similarity).
Biological Process
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process protein localization to plasma membraneIEA:Ensembl
Cellular Location
Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Cytoplasm, cytosol
Enriched at endoplasmic reticulum exit sites, also known as transitional endoplasmic reticulum (tER).
Involvement in disease
Craniolenticulosutural dysplasia (CLSD):
Autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms and skeletal defects.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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