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Mouse Anti-SEC24A Recombinant Antibody (CBXS-5028) (CBMAB-S2250-CQ)

This product is a mouse antibody that recognizes SEC24A. The antibody CBXS-5028 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all SEC24A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5028
Application
WB, IP, ELISA

Basic Information

Immunogen
SEC24A (XP_094581.5, 301aa-390aa) partial recombinant protein with GST tag
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SEC24 family, member A (S. cerevisiae)
Introduction
The protein encoded by this gene belongs to a family of proteins that are homologous to yeast Sec24. This protein is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
10802
UniProt ID
O95486
Alternative Names
SEC24 Homolog A, COPII Coat Complex Component; SEC24 (S. Cerevisiae) Related Gene Family, Member A; SEC24 Family, Member A (S. Cerevisiae); SEC24-Related Protein A; SEC24 Family Member A;
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:20427317, PubMed:17499046, PubMed:18843296).
Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes (PubMed:17499046, PubMed:18843296).
Biological Process
Biological Process cholesterol homeostasisIEA:Ensembl
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process positive regulation of protein secretionIEA:Ensembl
Biological Process regulation of cholesterol transportIEA:Ensembl
Cellular Location
Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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