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Rabbit Anti-SEC24C Recombinant Antibody (CBXS-0180) (CBMAB-S3166-CQ)

This product is a rabbit antibody that recognizes SEC24C. The antibody CBXS-0180 can be used for immunoassay techniques such as: WB, IF.
See all SEC24C antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-0180
Application
WB, IF

Basic Information

Specificity
Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SEC24 Homolog C, COPII Coat Complex Component
Introduction
The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified.
Entrez Gene ID
9632
UniProt ID
P53992
Alternative Names
SEC24 Homolog C, COPII Coat Complex Component; SEC24 (S. Cerevisiae) Related Gene Family, Member C; SEC24 Family, Member C (S. Cerevisiae); SEC24-Related Protein C; SEC24 Family Member C; KIAA0079;
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317).
Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296).
May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317).
May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).
Biological Process
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process intracellular protein transportIEA:InterPro
Cellular Location
Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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