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Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501)


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Tested Data
Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501) in ELISA
Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501) in ELISA
Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501) in WB
Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501) in WB
Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501) in WB
Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501) in WB
Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501) in IHC
Mouse Anti-SEC31A Recombinant Antibody (CBT2342) (V2LY-0625-LY501) in IHC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT2342
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Purified recombinant fragment of human SEC31A (AA: 429-571) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Entrez Gene ID
22872
Function
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (PubMed:10788476).
The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).
Biological Process
Biological Process COPII-coated vesicle cargo loadingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process endoplasmic reticulum organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process endoplasmic reticulum to Golgi vesicle-mediated transport1 PublicationNAS:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to calcium ionManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm
Cytoplasmic vesicle, COPII-coated vesicle membrane
Endoplasmic reticulum membrane
Cytoplasm, cytosol
Associates with membranes in a GTP-dependent manner (By similarity).
Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (PubMed:25201882, PubMed:28442536, PubMed:17428803).
Involvement in disease
Neurodevelopmental disorder with spastic quadriplegia, optic atrophy, seizures, and structural brain anomalies (NEDSOSB):
An autosomal recessive, congenital neurodevelopmental disorder characterized by intrauterine growth retardation, microcephaly, marked developmental delay, spastic quadriplegia with profound contractures, pseudobulbar palsy with recurrent aspirations, epilepsy, dysmorphism, neurosensory deafness, optic nerve atrophy with no eye fixation, and death in early childhood. Brain imaging shows semilobar holoprosencephaly and agenesis of corpus callosum.
PTM
An autosomal recessive, congenital neurodevelopmental disorder characterized by intrauterine growth retardation, microcephaly, marked developmental delay, spastic quadriplegia with profound contractures, pseudobulbar palsy with recurrent aspirations, epilepsy, dysmorphism, neurosensory deafness, optic nerve atrophy with no eye fixation, and death in early childhood. Brain imaging shows semilobar holoprosencephaly and agenesis of corpus callosum.
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For research use only. Not intended for any clinical use.

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