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Rabbit Anti-SEC62 Recombinant Antibody (CBXS-1629) (CBMAB-S4478-CQ)

This product is a rabbit antibody that recognizes SEC62. The antibody CBXS-1629 can be used for immunoassay techniques such as: WB, IP, IHC-P.
See all SEC62 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1629
Antibody Isotype
IgG
Application
WB, IP, IHC-P

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SEC62 Homolog, Preprotein Translocation Factor
Introduction
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
Entrez Gene ID
Human7095
Mouse69276
Rat294912
UniProt ID
HumanQ99442
MouseQ8BU14
RatQ7TP42
Alternative Names
SEC62 Homolog, Preprotein Translocation Factor; Translocation Protein 1; TLOC1; HTP-1; TP-1; Membrane Protein SEC62, S.Cerevisiae, Homolog Of;
Function
Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.
Biological Process
Biological Process cotranslational protein targeting to membraneManual Assertion Based On ExperimentTAS:ProtInc
Biological Process post-translational protein targeting to endoplasmic reticulum membraneManual Assertion Based On ExperimentIMP:MGI
Biological Process post-translational protein targeting to membrane, translocationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-196
Helical: 197-217
Lumenal: 218-234
Helical: 235-255
Cytoplasmic: 256-399
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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