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Mouse Anti-SEL1L Recombinant Antibody (MSel1) (CBMAB-S6441-CQ)

This product is a mouse antibody that recognizes SEL1L. The antibody MSel1 can be used for immunoassay techniques such as: IHC-Fr, IHC-P, IP, WB.
See all SEL1L antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
MSel1
Antibody Isotype
IgG1
Application
IHC-Fr, IHC-P, IP, WB

Basic Information

Immunogen
Recombinant human SEL1L (suppressor of lin-12-like protein)
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
150 mM sodium chloride, pH 7.4
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SEL1L ERAD E3 Ligase Adaptor Subunit
Introduction
The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human6400
Mouse20338
UniProt ID
HumanQ9UBV2
MouseQ9Z2G6
Alternative Names
SEL1L ERAD E3 Ligase Adaptor Subunit; Suppressor Of Lin-12-Like Protein 1; Suppressor Of Lin 12 (Sel-1), C. Elegans, Homolog Of; Sel-1 Suppressor Of Lin-12-Like 1 (C. Elegans); Sel-1 Suppressor Of Lin-12-Like (C. Elegans); Sel-1 Suppressor Of Lin-12-Like 1; Protein Sel-1 Homolog 1;
Function
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207).
Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Biological Process
Biological Process ERAD pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Notch signaling pathwayIEA:UniProtKB-KW
Biological Process protein secretionISS:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process retrograde protein transport, ER to cytosolManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process triglyceride metabolic processISS:UniProtKB
Biological Process ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Cellular Location
Endoplasmic reticulum membrane
Topology
Lumenal: 22-738
Helical: 739-759
Cytoplasmic: 760-794
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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