Mouse Anti-SEL1L Recombinant Antibody (MSel1) (CBMAB-S6441-CQ)

Name: Mouse Anti-SEL1L Recombinant Antibody (MSel1)
SKU: CBMAB-S6441-CQ
Rating: 5 (1 reviews)

See all SEL1L antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

MSel1

Application

IHC-Fr, IHC-P, IP, WB

Immunogen

Recombinant human SEL1L (suppressor of lin-12-like protein)

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

150 mM sodium chloride, pH 7.4

Preservative

0.02% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SEL1L ERAD E3 Ligase Adaptor Subunit

Introduction

The protein encoded by this gene is part of a protein complex required for the retrotranslocation or dislocation of misfolded proteins from the endoplasmic reticulum lumen to the cytosol, where they are degraded by the proteasome in a ubiquitin-dependent manner. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

Human	6400
Mouse	20338

UniProt ID

Human	Q9UBV2
Mouse	Q9Z2G6

Alternative Names

SEL1L ERAD E3 Ligase Adaptor Subunit; Suppressor Of Lin-12-Like Protein 1; Suppressor Of Lin 12 (Sel-1), C. Elegans, Homolog Of; Sel-1 Suppressor Of Lin-12-Like 1 (C. Elegans); Sel-1 Suppressor Of Lin-12-Like (C. Elegans); Sel-1 Suppressor Of Lin-12-Like 1; Protein Sel-1 Homolog 1;

Function

Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16186509, PubMed:29997207).
Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.

Biological Process

Biological Process ERAD pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Notch signaling pathwayIEA:UniProtKB-KW
Biological Process protein secretionISS:UniProtKB
Biological Process protein stabilizationManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process retrograde protein transport, ER to cytosolManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process triglyceride metabolic processISS:UniProtKB
Biological Process ubiquitin-dependent ERAD pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL

Cellular Location

Endoplasmic reticulum membrane

Topology

Lumenal: 22-738
Helical: 739-759
Cytoplasmic: 760-794

PTM

N-glycosylated.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SEL1L Recombinant Antibody (MSel1)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-SEL1L Recombinant Antibody (CBXS-0187) (CAT#: CBMAB-S3173-CQ)

Mouse Anti-SEL1L Recombinant Antibody (CBXS-3356) (CAT#: CBMAB-S6093-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry