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Rat Anti-SELPLG Recombinant Antibody (CBYY-C2122) (CBMAB-C3560-YY)

This product is rat antibody that recognizes SELPLG. The antibody CBYY-C2122 can be used for immunoassay techniques such as: FC
See all SELPLG antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-C2122
Antibody Isotype
IgG1, κ
Application
FC

Basic Information

Immunogen
PSGL-1 human IgG1 fusion protein
Specificity
Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1.0 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Selectin P Ligand
Entrez Gene ID
20345
UniProt ID
Q62170
Alternative Names
Transferrin Receptor; TFR1; TRFR; P90; TFR; TR; T9;
Function
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
(Microbial infection) Acts as a receptor for enterovirus 71.
Biological Process
Biological Process cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process cellular response to interleukin-6Manual Assertion Based On ExperimentIDA:MGI
Biological Process hemopoiesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process leukocyte adhesive activationISS:UniProtKB
Biological Process leukocyte migrationManual Assertion Based On ExperimentIDA:CAFA
Biological Process leukocyte tethering or rollingManual Assertion Based On ExperimentIDA:CAFA
Cellular Location
Membrane
Topology
Extracellular: 18-320
Helical: 321-341
Cytoplasmic: 342-412
PTM
Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation.
Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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