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Mouse Anti-SEMA4A Recombinant Antibody (CBXS-1915) (CBMAB-S0138-CQ)

This product is a mouse antibody that recognizes SEMA4A. The antibody CBXS-1915 can be used for immunoassay techniques such as: FC.
See all SEMA4A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1915
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
NS0-derived recombinant human Semaphorin 4A, Gly32-His683, Accession # Q9H3S1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Semaphorin 4A
Introduction
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Entrez Gene ID
64218
UniProt ID
Q9H3S1
Alternative Names
Semaphorin 4A; Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) And Short Cytoplasmic Domain, (Semaphorin) 4A; Semaphorin-B; Sema B; SEMAB; SEMB; Semaphorin-4A; CORD10; RP35;
Function
Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (By similarity).
Regulates glutamatergic and GABAergic synapse development (By similarity).
Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (By similarity).
Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (By similarity).
Promotes phosphorylation of TIMD2 (By similarity).
Inhibits angiogenesis (By similarity).
Promotes axon growth cone collapse (By similarity).
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (By similarity).
Biological Process
Biological Process angiogenesisIEA:UniProtKB-KW
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of angiogenesisIEA:Ensembl
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of excitatory synapse assemblyISS:UniProtKB
Biological Process positive regulation of inhibitory synapse assemblyISS:UniProtKB
Biological Process regulation of cell shapeIEA:Ensembl
Biological Process regulation of endothelial cell migrationIEA:Ensembl
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process T-helper 1 cell differentiationIEA:Ensembl
Cellular Location
Cell membrane
Involvement in disease
Retinitis pigmentosa 35 (RP35):
A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Cone-rod dystrophy 10 (CORD10):
An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.
Topology
Extracellular: 33-683
Helical: 684-704
Cytoplasmic: 705-761
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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