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Rat Anti-SEMA6B Recombinant Antibody (CBXS-5711) (CBMAB-S0579-CQ)

This product is a rat antibody that recognizes SEMA6B. The antibody CBXS-5711 can be used for immunoassay techniques such as: WB.
See all SEMA6B antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXS-5711
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Mouse recombinant protein of Semaphorin 6B extracellular domain
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
Introduction
This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development.
Entrez Gene ID
20359
UniProt ID
O54951
Alternative Names
Sema; Seman; VIb; semaZ
Function
Functions as a cell surface repellent for mossy fibers of developping neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons.
(Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium.
Biological Process
Biological Process axon guidanceISS:UniProtKB
Biological Process central nervous system developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process hippocampus developmentISS:UniProtKB
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Epilepsy, progressive myoclonic 11 (EPM11):
A form of progressive myoclonic epilepsy, a clinically and genetically heterogeneous group of disorders defined by the combination of action and reflex myoclonus, other types of epileptic seizures, and progressive neurodegeneration and neurocognitive impairment. EPM11 is an autosomal dominant form. Clinical features include normal or mildly delayed early development, developmental regression after seizures onset, inability to walk, severely impaired intellectual development, poor or absent speech, spasticity, ataxia, and intention tremor. Brain imaging shows cerebellar atrophy in some patients.
Topology
Extracellular: 26-603
Helical: 604-624
Cytoplasmic: 625-888
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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