Sign in or Register   Sign in or Register
  |  

Mouse Anti-SEMA6D Recombinant Antibody (CBXS-1741) (CBMAB-S4567-CQ)

This product is a mouse antibody that recognizes SEMA6D. The antibody CBXS-1741 can be used for immunoassay techniques such as: WB.
See all SEMA6D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1741
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
NS0-derived recombinant human Semaphorin 6D, Ser22-His660, Accession # Q8NFY4
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Introduction
Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner.
Entrez Gene ID
80031
UniProt ID
Q8NFY4
Alternative Names
Semaphorin 6D; Sema Domain, Transmembrane Domain (TM), And Cytoplasmic Domain, (Semaphorin) 6D; Semaphorin-6D; KIAA1479;
Function
Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections.
Biological Process
Biological Process axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of axon extensionIDA:UniProtKB
Biological Process negative regulation of axon extension involved in axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of smooth muscle cell migrationIEA:Ensembl
Biological Process neural crest cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of smooth muscle cell migrationIEA:Ensembl
Biological Process semaphorin-plexin signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process smooth muscle cell migrationIEA:Ensembl
Biological Process ventricular system developmentIEA:Ensembl
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Cell membrane
Isoform 3
Cell membrane
Isoform 4
Cell membrane
Isoform 5
Cell membrane
Isoform 7
Cytoplasm
Topology
Extracellular: 21-662
Helical: 663-683
Cytoplasmic: 684-1073
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SEMA6D Recombinant Antibody (CBXS-1741)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare