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Mouse Anti-SENP5 Recombinant Antibody (CBXS-4800) (CBMAB-S2026-CQ)

This product is a mouse antibody that recognizes SENP5. The antibody CBXS-4800 can be used for immunoassay techniques such as: WB, IP, IF, IHC-P, ELISA.
See all SENP5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4800
Application
WB, IP, IF, IHC-P, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SUMO1/sentrin specific peptidase 5
Introduction
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).
Entrez Gene ID
205564
UniProt ID
Q96HI0
Alternative Names
SUMO1/Sentrin Specific Peptidase 5; Sentrin/SUMO-Specific Protease SENP5; SUMO1/Sentrin Specific Protease 5; EC 3.4.22.-; EC 3.4.22;
Function
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
Biological Process
Biological Process cell cycleIEA:UniProtKB-KW
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process protein desumoylationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus, nucleolus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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