Mouse Anti-SERPING1 Recombinant Antibody (CBXS-2359) (CBMAB-S5117-CQ)

Name: Mouse Anti-SERPING1 Recombinant Antibody (CBXS-2359)
SKU: CBMAB-S5117-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-2359

Application

ELISA

Immunogen

Purified SERPING1 from human blood

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

0.09% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Serpin Family G Member 1

Introduction

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.

Entrez Gene ID

710

UniProt ID

P05155

Alternative Names

Serpin Family G Member 1; Serpin Peptidase Inhibitor, Clade G (C1 Inhibitor), Member 1; Plasma Protease C1 Inhibitor; C1 Esterase Inhibitor; C1-Inhibiting Factor; Serpin G1; C1INH; C1NH; C1IN;

Function

Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.

Biological Process

Biological Process agingIEA:Ensembl
Biological Process blood circulationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process blood coagulationIEA:UniProtKB-KW
Biological Process complement activation, classical pathwayIEA:UniProtKB-KW
Biological Process fibrinolysisIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process negative regulation of complement activation, lectin pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endopeptidase activityManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Secreted

Involvement in disease

Angioedema, hereditary (HAE):
An autosomal dominant disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. Hereditary angioedema due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In hereditary angioedema type 1, serum levels of C1 esterase inhibitor are decreased, while in type 2, the levels are normal or elevated, but the protein is non-functional.

PTM

Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor).
Can be proteolytically cleaved by E.coli stcE.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

SERPING1 Matched Antibody Pair (1074) (CAT#: APMAB-1074LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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