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Rabbit Anti-SETD1B Recombinant Antibody (D1U5D) (CBMAB-CP2399-LY)

The product is antibody recognizes SETD1B. The antibody D1U5D immunoassay techniques such as: WB,IP.
See all SETD1B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Cattle, Pig, Horse
Clone
D1U5D
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val204 of human SET1B protein.
Specificity
Human, Mouse, Monkey, Cattle, Pig, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SET Domain Containing 1B
Introduction
SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
Human23067
Mouse208043
Monkey703717
Cattle514102
Pig100156137
Horse100146430
UniProt ID
HumanQ9UPS6
MouseQ8CFT2
MonkeyF7E7X9
CattleF1N6Y5
HorseF7DJA2
Alternative Names
SET Domain Containing 1B; SET Domain-Containing Protein 1B; Lysine N-Methyltransferase 2G; EC 2.1.1.43; HSET1B; Set1B;
Function
Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism (PubMed:25561738, PubMed:17355966).
Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:17355966).
Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (By similarity).
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process histone H3-K4 dimethylationManual Assertion Based On ExperimentIDA:CACAO
Biological Process histone H3-K4 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histone H3-K4 monomethylationManual Assertion Based On ExperimentIDA:CACAO
Biological Process histone H3-K4 trimethylationManual Assertion Based On ExperimentIDA:CACAO
Cellular Location
Nucleus speckle
Chromosome
Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SET1B each bind to a unique set of target genes.
Involvement in disease
Intellectual developmental disorder with seizures and language delay (IDDSELD):
An autosomal dominant neurodevelopmental disorder characterized by mild to profound intellectual development impairment, speech and language delay, and seizures. Autism and anxiety are common features. Facial dysmorphism, tapering fingers, and pigmentary skin changes may also be observed.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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