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Mouse Anti-SETDB2 Recombinant Antibody (2F4) (CBMAB-A8017-LY)

The product is antibody recognizes SETDB2. The antibody 2F4 immunoassay techniques such as: WB, ELISA.
See all SETDB2 antibodies
Published Data
Fig. 1 Western blot analysis shows the expression of SETDB2 after E2A-PBX1 knockdown in RCH-ACV and 697 cell lines.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2F4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SETDB2 (NP_114121.1, 451 a.a. ~ 550 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SET domain, bifurcated 2
Introduction
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).[supplied by OMIM
Entrez Gene ID
83852
UniProt ID
Q96T68
Alternative Names
C13orf4; CLLD8; CLLL8; DKFZp586I0123; DKFZp761J1217; KMT1F
Function
Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Biological Process
Biological Process cell divisionIEA:UniProtKB-KW
Biological Process chromosome segregationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process heart loopingISS:UniProtKB
Biological Process heterochromatin organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process histone H3-K9 methylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process left/right axis specificationISS:UniProtKB
Biological Process mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of DNA-templated transcriptionISS:UniProtKB
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of DNA methylation-dependent heterochromatin assemblyManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Chromosome
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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