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Mouse Anti-SFRS6 Recombinant Antibody (6A10) (CBMAB-A8037-LY)

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Datasheet
SDS
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Basic Information

Host Animal
Mouse
Clone
6A10
Application
WB, ELISA
Immunogen
SFRS6 (NP_006266, 1 a.a. ~ 75 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
splicing factor, arginine/serine-rich 6
Introduction
The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. [provided by RefSeq]
Entrez Gene ID
6431
UniProt ID
Q13247
Alternative Names
B52; FLJ08061; MGC5045; SRP55
Function
Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.
Biological Process
Biological Process alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA splice site selectionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell deathManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of keratinocyte differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of type B pancreatic cell apoptotic processIEA:Ensembl
Biological Process positive regulation of epithelial cell proliferation involved in lung morphogenesisManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:MGI
Biological Process regulation of keratinocyte proliferationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of wound healingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to insulinIEA:Ensembl
Cellular Location
Nucleus
Nucleus speckle
PTM
Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-SFRS6 Recombinant Antibody (5G6) (CAT#: CBMAB-A8036-LY)

Isotype control

For research use only. Not intended for any clinical use.

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