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Mouse Anti-SH2B3 Recombinant Antibody (2D8) (CBMAB-L0270-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to SH2B Adaptor Protein 3 (SH2B3). The antibody can be used for immunoassay techniques, such as WB, FC, IHC, ICC, IF, IHC-P.
See all SH2B3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D8
Antibody Isotype
IgG1
Application
WB, FC, IHC, ICC, IF, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human SH2B3 (NP_005466) produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SH2B Adaptor Protein 3
Introduction
SH2B3 is a member of the SH2B adaptor family of proteins, which play a role in a range of signaling activities by growth factor and cytokine receptors. SH2B3 is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. It has been found that alternatively spliced transcript variants encode different isoforms for this gene.
Entrez Gene ID
10019
UniProt ID
Q9UQQ2
Alternative Names
SH2B Adaptor Protein 3; Lymphocyte-Specific Adapter Protein Lnk; Signal Transduction Protein Lnk; LNK; Lymphocyte Adaptor Protein; Lymphocyte Adapter Protein; SH2B Adapter Protein 3; IDDM20
Function
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
Biological Process
Biological Process cellular response to chemokineISS:ARUK-UCL
Biological Process cellular response to interleukin-3ISS:ARUK-UCL
Biological Process embryonic hemopoiesisISS:BHF-UCL
Biological Process erythrocyte developmentManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process hematopoietic stem cell differentiationIEA:Ensembl
Biological Process intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process megakaryocyte developmentISS:ARUK-UCL
Biological Process monocyte homeostasisBy SimilarityISS:BHF-UCL
Biological Process negative regulation of cell population proliferationISS:ARUK-UCL
Biological Process negative regulation of chemokine-mediated signaling pathwayISS:ARUK-UCL
Biological Process negative regulation of Kit signaling pathwayISS:BHF-UCL
Biological Process negative regulation of MAP kinase activityISS:ARUK-UCL
Biological Process negative regulation of platelet aggregationBy SimilarityISS:BHF-UCL
Biological Process negative regulation of protein kinase B signalingISS:ARUK-UCL
Biological Process negative regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of response to cytokine stimulusManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of tyrosine phosphorylation of STAT proteinISS:ARUK-UCL
Biological Process neutrophil homeostasisBy SimilarityISS:BHF-UCL
Biological Process thrombopoietin-mediated signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
cytosol
plasma membrane
Involvement in disease
Celiac disease 13 (CELIAC13):
A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.
Diabetes mellitus, insulin-dependent (IDDM):
A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
PTM
Tyrosine phosphorylated by LCK.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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