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Mouse Anti-SIGLEC12 Recombinant Antibody (CBXS-0967) (CBMAB-S3876-CQ)

This product is a mouse antibody that recognizes SIGLEC12. The antibody CBXS-0967 can be used for immunoassay techniques such as: S-ELISA, ELISA, WB.
See all SIGLEC12 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0967
Antibody Isotype
IgG2a, κ
Application
S-ELISA, ELISA, WB

Basic Information

Immunogen
SIGLEC12 (NP_443729.1, 503 a.a.-595 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sialic acid binding Ig-like lectin 12
Introduction
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
89858
UniProt ID
Q96PQ1
Alternative Names
Sialic Acid Binding Ig Like Lectin 12 (Gene/Pseudogene); Sialic Acid-Binding Ig-Like Lectin-Like 1; Sialic Acid Binding Ig-Like Lectin 12; SIGLEC-Like 1; SIGLECL1; SLG; Sialic Acid Binding Ig-Like Lectin 12 (Gene/Pseudogene);
Function
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Biological Process
Cell adhesion
Cellular Location
Membrane
Topology
Extracellular: 19-481
Helical: 482-502
Cytoplasmic: 503-595
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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