Sign in or Register   Sign in or Register
  |  

Mouse Anti-SIL1 Recombinant Antibody (CBXS-4760) (CBMAB-S1989-CQ)

This product is a mouse antibody that recognizes SIL1. The antibody CBXS-4760 can be used for immunoassay techniques such as: FC, IF, IHC, IHC-P, WB.
See all SIL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4760
Antibody Isotype
IgG1
Application
FC, IF, IHC, IHC-P, WB

Basic Information

Immunogen
Recombinant full length human SIL1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SIL1 Nucleotide Exchange Factor
Introduction
This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized.
Entrez Gene ID
64374
UniProt ID
Q9H173
Alternative Names
SIL1 Nucleotide Exchange Factor; BiP-Associated Protein; BAP; SIL1 Homolog, Endoplasmic Reticulum Chaperone (S. Cerevisiae); SIL1-Like Protein Endoplasmic Reticulum Chaperone; SIL1 Homolog, Endoplasmic Reticulum Chaperone;
Function
Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5.
Biological Process
Biological Process cotranslational protein targeting to membraneISS:FlyBase
Biological Process intracellular protein transport1 PublicationNAS:UniProtKB
Biological Process protein folding1 PublicationNAS:UniProtKB
Cellular Location
Endoplasmic reticulum lumen
Involvement in disease
Marinesco-Sjoegren syndrome (MSS):
Autosomal recessive multisystem disorder which is characterized by cerebellar ataxia due to cerebellar atrophy, with Purkinje and granule cell loss and myopathy featuring marked muscle replacement with fat and connective tissue. Other cardinal features include bilateral cataracts, hypergonadotrophic hypogonadism and mild to severe intellectual disability. Skeletal abnormalities, short stature, dysarthria, strabismus and nystagmus are also frequent findings. Mutational inactivation of this protein may result in ER stress-induced cell death signaling or malfunctioning chaperone machineries that mishandle client proteins which are critical for the organs targeted in MSS.
PTM
N-glycosylated.
Ubiquitinated by the CRL2(FEM1A) and CRL2(FEM1C) complexes, which recognize the -Lys-Xaa-Xaa-Arg C-degron at the C-terminus, leading to its degradation.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SIL1 Recombinant Antibody (CBXS-4760)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare