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Mouse Anti-SKIV2L Recombinant Antibody (CBXS-4064) (CBMAB-S1323-CQ)

This product is a mouse antibody that recognizes SKIV2L. The antibody CBXS-4064 can be used for immunoassay techniques such as: WB.
See all SKIV2L antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4064
Antibody Isotype
IgG2a, κ
Application
WB

Basic Information

Immunogen
SKIV2L (NP_008860, 1125 a.a.-1233 a.a) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites fluid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ski2 Like RNA Helicase
Introduction
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex.
Entrez Gene ID
6499
UniProt ID
Q15477
Alternative Names
Ski2 Like RNA Helicase; SKI2 Homolog, Superkiller Viralicidic Activity 2-Like; Helicase-Like Protein; SKIV2; DDX13; SKI2W; SKI2; HLP; Superkiller Viralicidic Activity 2 (S. Cerevisiae Homolog)-Like; Superkiller Viralicidic Activity 2-Like (S. Cerevisiae);
Function
Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
Biological Process
Biological Process nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Cytoplasm
Involvement in disease
Trichohepatoenteric syndrome 2 (THES2):
A syndrome characterized by intrauterine growth retardation, severe diarrhea in infancy requiring total parenteral nutrition, facial dysmorphism, immunodeficiency, and hair abnormalities, mostly trichorrhexis nodosa. Hepatic involvement contributes to the poor prognosis of affected patients.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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