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Mouse Anti-SLC12A2 Recombinant Antibody (T4) (CBMAB-N4270-WJ)

This product is a Mouse antibody that recognizes SLC12A2. The antibody T4 can be used for immunoassay techniques such as: ICC, IHC, IP, WB.
See all SLC12A2 antibodies

Summary

Host Animal
Mouse
Specificity
Cattle, Dog, Human, Rabbit, Rat
Clone
T4
Application
ICC, IHC, IP, WB

Basic Information

Specificity
Cattle, Dog, Human, Rabbit, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 12 Member 2
Introduction
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Entrez Gene ID
Human6558
Cattle286845
Rat83629
Dog481490
Rabbit100328591
UniProt ID
HumanP55011
CattleF1MS08
RatQ9QX10
DogA0A8I3NAK7
RabbitP55015
Alternative Names
Solute Carrier Family 12 Member 2; Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 1; Basolateral Na-K-Cl Symporter; Solute Carrier Family 12 (Sodium/Potassium/Chloride Transporter), Member 2; Protein Phosphatase 1, Regulatory Subunit 141; NKCC1;
Function
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:32294086).
Plays a vital role in the regulation of ionic balance and cell volume.
Biological Process
Biological Process agingIEA:Ensembl
Biological Process ammonium transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell volume homeostasisISS:ARUK-UCL
Biological Process cellular chloride ion homeostasisISS:ARUK-UCL
Biological Process cellular potassium ion homeostasisISS:ARUK-UCL
Biological Process cellular response to chemokineManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cellular response to potassium ionISS:ARUK-UCL
Biological Process cellular sodium ion homeostasisISS:ARUK-UCL
Biological Process chloride ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chloride transmembrane transportISS:ARUK-UCL
Biological Process gamma-aminobutyric acid signaling pathwayBy SimilarityISS:ARUK-UCL
Biological Process hyperosmotic responseIEA:Ensembl
Biological Process inorganic anion import across plasma membraneISS:ARUK-UCL
Biological Process inorganic cation import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process ion transportTAS:Reactome
Biological Process maintenance of blood-brain barrierISS:ARUK-UCL
Biological Process negative regulation of vascular wound healingISS:ARUK-UCL
Biological Process positive regulation of aspartate secretionISS:ARUK-UCL
Biological Process positive regulation of cell volumeIEA:Ensembl
Biological Process potassium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process potassium ion import across plasma membraneISS:ARUK-UCL
Biological Process regulation of matrix metallopeptidase secretionISS:ARUK-UCL
Biological Process regulation of spontaneous synaptic transmissionBy SimilarityISS:ARUK-UCL
Biological Process sodium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion import across plasma membraneISS:ARUK-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process T cell chemotaxisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process transepithelial ammonium transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process transepithelial chloride transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Basolateral cell membrane
Involvement in disease
Deafness, autosomal dominant, 78 (DFNA78):
A form of non-syndromic deafness characterized by congenital, profound bilateral sensorineural hearing loss affecting all frequencies. Some patients may have mild motor delay early in life due to vestibular dysfunction. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Delpire-McNeill syndrome (DELMNES):
An autosomal dominant neurodevelopmental disorder characterized by global developmental delay, hypotonia with delayed or absent walking, bilateral sensorineural deafness, poor or absent speech, and mild to severe intellectual disability. Additional variable features may include spasticity or minor involvement of other organ systems, such as hip dislocation or ventricular septal defect.
Kilquist syndrome (KILQS):
An autosomal recessive, multisystem disorder characterized by severe global developmental delay, sensorineural hearing loss, poor overall growth, mild facial dysmorphism, gastrointestinal anomalies such as gastroesophageal reflux or midgut malrotation, and a striking lack of tear fluid, saliva, and sweat.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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