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Mouse Anti-SLC12A3 Recombinant Antibody (5C6.10.4) (CBMAB-N4272-WJ)

This product is a Mouse antibody that recognizes SLC12A3. The antibody 5C6.10.4 can be used for immunoassay techniques such as: FC, ELISA, WB, IP, IF, FC.
See all SLC12A3 antibodies

Summary

Host Animal
Mouse
Specificity
Pig, Fish, Human, Hamster, Rat, Cattle, Horse, Dog
Clone
5C6.10.4
Antibody Isotype
IgM
Application
FC, ELISA, WB, IP, IF, FC

Basic Information

Specificity
Pig, Fish, Human, Hamster, Rat, Cattle, Horse, Dog
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 12 Member 3
Introduction
This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human6559
Cattle404171
Rat54300
Dog478118
Pig110260927
Horse100051953
Hamster100758081
UniProt ID
Alternative Names
Solute Carrier Family 12 Member 3; Solute Carrier Family 12 (Sodium/Chloride Transporter), Member 3; Thiazide-Sensitive Sodium-Chloride Cotransporter; Na-Cl Cotransporter; Na-Cl Symporter; NCC;
Function
Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:21613606, PubMed:22009145).
Receptor for the pro-inflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1 (By similarity).
Biological Process
Biological Process cell volume homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to inorganic substanceIEA:Ensembl
Biological Process chloride ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chloride transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ion transportTAS:Reactome
Biological Process potassium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process potassium ion import across plasma membraneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein phosphorylationIEA:Ensembl
Biological Process response to aldosteroneIEA:Ensembl
Biological Process response to dietary excessIEA:Ensembl
Biological Process signal transductionIEA:Ensembl
Biological Process sodium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion transmembrane transportISS:BHF-UCL
Biological Process sodium ion transportISS:UniProtKB
Cellular Location
Cell membrane
Apical cell membrane
Topology
Cytoplasmic: 1-135
Helical: 136-156
Extracellular: 159-179
Helical: 180-218
Cytoplasmic: 219-239
Helical: 262-282
Extracellular: 283-286
Helical: 287-307
Cytoplasmic: 340-360
Helical: 361-377
Extracellular: 378-398
Helical: 453-473
Cytoplasmic: 474-511
Helical: 512-532
Extracellular: 535-555
Helical: 556-577
Cytoplasmic: 578-598
Helical: 661-681
Extracellular: 682-1021
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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