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Mouse Anti-SLC12A6 Recombinant Antibody (CBXS-0429) (CBMAB-S3379-CQ)

This product is a mouse antibody that recognizes SLC12A6. The antibody CBXS-0429 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all SLC12A6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0429
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Potassium Chloride Cotransporters 3
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 12 Member 6
Introduction
This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.
Entrez Gene ID
9990
UniProt ID
Q9UHW9
Alternative Names
Solute Carrier Family 12 Member 6; Solute Carrier Family 12 (Potassium/Chloride Transporter), Member 6; Electroneutral Potassium-Chloride Cotransporter 3; K-Cl Cotransporter 3; KCC3; Agenesis Of Corpus Callosum And Peripheral Neuropathy (Andermann Syndrome); Solute Carrier Family 12 (Potassium/Chloride Transporters), Member 6; Potassium Chloride Cotransporter KCC3a-S3; Potassium Chloride Cotransporter 3;
Function
Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
Biological Process
Biological Process ammonium import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process angiogenesis1 PublicationNAS:UniProtKB
Biological Process cell volume homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular hypotonic responseIMP:ParkinsonsUK-UCL
Biological Process cellular hypotonic salinity responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular response to glucose stimulusIEA:Ensembl
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chloride ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chloride transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process potassium ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process potassium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ParkinsonsUK-UCL
Cellular Location
Basolateral cell membrane
Involvement in disease
Agenesis of the corpus callosum, with peripheral neuropathy (ACCPN):
A disease that is characterized by severe progressive sensorimotor neuropathy, intellectual disability, dysmorphic features and complete or partial agenesis of the corpus callosum.
Topology
Cytoplasmic: 1-185
Helical: 186-208
Extracellular: 209-223
Helical: 224-245
Cytoplasmic: 246-271
Helical: 272-295
Extracellular: 296-318
Helical: 319-343
Cytoplasmic: 344-346
Helical: 347-371
Extracellular: 372-479
Helical: 480-501
Cytoplasmic: 502-515
Helical: 516-543
Extracellular: 544-557
Helical: 558-581
Cytoplasmic: 582-620
Helical: 621-644
Extracellular: 645-647
Helical: 648-670
Cytoplasmic: 671-676
Helical: 677-695
Extracellular: 696
Helical: 697-719
Cytoplasmic: 720-1150
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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