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Mouse Anti-SLC18A3 Recombinant Antibody (S6-38) (CBMAB-V0260-LY)

This product is antibody recognizes SLC18A3. The antibody S6-38 immunoassay techniques such as: WB, IHC-P, IHC-Fr, FC.
See all SLC18A3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S6-38
Antibody Isotype
IgG1
Application
WB, IHC-P, IHC-Fr, FC

Basic Information

Immunogen
Synthetic peptide amino acids 521-532 of human VACht
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Solute Carrier Family 18 Member A3
Introduction
This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene.
Entrez Gene ID
Human6572
Mouse20508
Rat60422
UniProt ID
HumanQ16572
MouseO35304
RatQ62666
Alternative Names
CMS21; VACHT
Function
Involved in acetylcholine transport into synaptic vesicles.
Biological Process
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neurotransmitter transportTAS:Reactome
Cellular Location
Membrane
Involvement in disease
Myasthenic syndrome, congenital, 21, presynaptic (CMS21):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS21 is an autosomal recessive, pre-synaptic form characterized by ptosis, ophthalmoplegia, fatigable weakness, apneic crises, and deterioration of symptoms in cold water. Learning difficulties and left ventricular dysfunction may be present in some patients.
Topology
Cytoplasmic: 1-33
Helical: 34-54
Lumenal: 55-125
Helical: 126-146
Cytoplasmic: 147-152
Helical: 153-173
Lumenal: 174-182
Helical: 183-203
Cytoplasmic: 204-213
Helical: 214-234
Lumenal: 235-242
Helical: 243-263
Cytoplasmic: 264-289
Helical: 290-310
Lumenal: 311-325
Helical: 326-346
Cytoplasmic: 347-356
Helical: 357-377
Lumenal: 378-388
Helical: 389-409
Cytoplasmic: 410-422
Helical: 423-443
Lumenal: 444-447
Helical: 448-468
Cytoplasmic: 469-532
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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