Mouse Anti-SLC18A3 Recombinant Antibody (S6-38) (CBMAB-V0260-LY)

Name: Mouse Anti-SLC18A3 Recombinant Antibody (S6-38)
SKU: CBMAB-V0260-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

S6-38

Application

WB, IHC-P, IHC-Fr, FC

Immunogen

Synthetic peptide amino acids 521-532 of human VACht

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 18 Member A3

Introduction

This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene.

Entrez Gene ID

Human	6572
Mouse	20508
Rat	60422

UniProt ID

Human	Q16572
Mouse	O35304
Rat	Q62666

Alternative Names

CMS21; VACHT

Function

Involved in acetylcholine transport into synaptic vesicles.

Biological Process

Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process neurotransmitter transportTAS:Reactome

Cellular Location

Membrane

Involvement in disease

Myasthenic syndrome, congenital, 21, presynaptic (CMS21):
A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness. CMS21 is an autosomal recessive, pre-synaptic form characterized by ptosis, ophthalmoplegia, fatigable weakness, apneic crises, and deterioration of symptoms in cold water. Learning difficulties and left ventricular dysfunction may be present in some patients.

Topology

Cytoplasmic: 1-33
Helical: 34-54
Lumenal: 55-125
Helical: 126-146
Cytoplasmic: 147-152
Helical: 153-173
Lumenal: 174-182
Helical: 183-203
Cytoplasmic: 204-213
Helical: 214-234
Lumenal: 235-242
Helical: 243-263
Cytoplasmic: 264-289
Helical: 290-310
Lumenal: 311-325
Helical: 326-346
Cytoplasmic: 347-356
Helical: 357-377
Lumenal: 378-388
Helical: 389-409
Cytoplasmic: 410-422
Helical: 423-443
Lumenal: 444-447
Helical: 448-468
Cytoplasmic: 469-532

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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