Sign in or Register   Sign in or Register
  |  

Mouse Anti-SLC19A1 Recombinant Antibody (890513) (CBMAB-R0187-CN)

This product is a Mouse antibody that recognizes SLC19A1. The antibody 890513 can be used for immunoassay techniques such as: FC, CyTOF.
See all SLC19A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
890513
Antibody Isotype
IgG2a
Application
FC, CyTOF

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human Reduced Folate Carrier/SLC19A1, Met1-Gln591, Accession # P41440
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose

Target

Full Name
solute carrier family 19 (folate transporter), member 1
Introduction
The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Entrez Gene ID
6573
UniProt ID
P41440
Alternative Names
Solute Carrier Family 19 Member 1; Solute Carrier Family 19 (Folate Transporter), Member 1; Reduced Folate Carrier Protein; Placental Folate Transporter; Intestinal Folate Carrier 1; Reduced Folate Carrier 1; Folate Transporter 1; IFC-1;
Function
Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31511694, PubMed:31126740, PubMed:32276275).
Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31511694, PubMed:31126740).
Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803).
Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803).
Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31511694, PubMed:31126740).
5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803).
Biological Process
Biological Process cyclic-GMP-AMP transmembrane import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process female pregnancyIEA:Ensembl
Biological Process folate import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process folate transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process folic acid metabolic processTAS:Reactome
Biological Process folic acid transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process methotrexate transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process organic anion transportISS:ARUK-UCL
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrierManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process xenobiotic transmembrane transportISS:ARUK-UCL
Cellular Location
Cell membrane
Apical cell membrane
Basolateral cell membrane
Involvement in disease
Megaloblastic anemia, folate-responsive (MEGAF):
An autosomal recessive metabolic disorder characterized by megaloblastic anemia resulting from decreased folate transport into erythrocytes. Disease manifestations include hemolytic anemia, hyperhomocysteinemia, and low vitamin B12. Serum folate levels are normal, but erythrocyte folate levels are decreased. Treatment with oral folate corrects the anemia and normalizes homocysteine.
Topology
Cytoplasmic: 1-23
Helical: 24-44
Extracellular: 45-70
Helical: 71-89
Cytoplasmic: 90-95
Helical: 96-116
Extracellular: 117-123
Helical: 124-144
Cytoplasmic: 145-159
Helical: 160-177
Extracellular: 178-186
Helical: 187-203
Cytoplasmic: 204-259
Helical: 260-287
Extracellular: 288-309
Helical: 310-327
Cytoplasmic: 328-333
Helical: 334-354
Extracellular: 355-360
Helical: 361-378
Cytoplasmic: 379-394
Helical: 395-419
Extracellular: 420-433
Helical: 434-454
Cytoplasmic: 455-591
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SLC19A1 Recombinant Antibody (890513)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare