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Mouse Anti-SLC19A2 (AA 209-286) Recombinant Antibody (CBXS-0432) (CBMAB-S3382-CQ)

This product is a mouse antibody that recognizes SLC19A2. The antibody CBXS-0432 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC19A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0432
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 209-286

Target

Full Name
solute carrier family 19 (thiamine transporter), member 2
Introduction
This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
10560
UniProt ID
O60779
Alternative Names
Solute Carrier Family 19 Member 2; Solute Carrier Family 19 (Thiamine Transporter), Member 2; ThTr-1; THTR1; TRMA; THT1; TC1;
Function
High-affinity transporter for the intake of thiamine.
Biological Process
Biological Process spermatogenesisIEA:Ensembl
Biological Process thiamine transmembrane transportISS:BHF-UCL
Biological Process thiamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process thiamine-containing compound metabolic processTAS:Reactome
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Thiamine-responsive megaloblastic anemia syndrome (TRMA):
An autosomal recessive disease characterized by megaloblastic anemia, diabetes mellitus, and sensorineural deafness. Onset is typically between infancy and adolescence, but all of the cardinal findings are often not present initially. The anemia, and sometimes the diabetes, improves with high doses of thiamine. Other more variable features include optic atrophy, congenital heart defects, short stature, and stroke.
Topology
Cytoplasmic: 1-28
Helical: 29-46
Extracellular: 47-72
Helical: 73-91
Cytoplasmic: 92-99
Helical: 100-118
Extracellular: 119-128
Helical: 129-149
Cytoplasmic: 150-165
Helical: 166-185
Extracellular: 186-191
Helical: 192-208
Cytoplasmic: 209-285
Helical: 286-310
Extracellular: 311-337
Helical: 338-354
Cytoplasmic: 355-363
Helical: 364-380
Extracellular: 381-386
Helical: 387-409
Cytoplasmic: 410-419
Helical: 420-443
Extracellular: 444-455
Helical: 456-479
Cytoplasmic: 480-497
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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