Mouse Anti-SLC19A2 Recombinant Antibody (CBXS-3276) (CBMAB-S6016-CQ)

Name: Mouse Anti-SLC19A2 Recombinant Antibody (CBXS-3276)
SKU: CBMAB-S6016-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBXS-3276

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa209-285 from SLC19A2 (NP_008927.1) with GST tag

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

solute carrier family 19 (thiamine transporter), member 2

Introduction

This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. Two transcript variants encoding different isoforms have been found for this gene.

Entrez Gene ID

10560

UniProt ID

O60779

Alternative Names

Solute Carrier Family 19 Member 2; Solute Carrier Family 19 (Thiamine Transporter), Member 2; ThTr-1; THTR1; TRMA; THT1; TC1;

Function

High-affinity transporter for the intake of thiamine.

Biological Process

Biological Process spermatogenesisIEA:Ensembl
Biological Process thiamine transmembrane transportISS:BHF-UCL
Biological Process thiamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process thiamine-containing compound metabolic processTAS:Reactome
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Thiamine-responsive megaloblastic anemia syndrome (TRMA):
An autosomal recessive disease characterized by megaloblastic anemia, diabetes mellitus, and sensorineural deafness. Onset is typically between infancy and adolescence, but all of the cardinal findings are often not present initially. The anemia, and sometimes the diabetes, improves with high doses of thiamine. Other more variable features include optic atrophy, congenital heart defects, short stature, and stroke.

Topology

Cytoplasmic: 1-28
Helical: 29-46
Extracellular: 47-72
Helical: 73-91
Cytoplasmic: 92-99
Helical: 100-118
Extracellular: 119-128
Helical: 129-149
Cytoplasmic: 150-165
Helical: 166-185
Extracellular: 186-191
Helical: 192-208
Cytoplasmic: 209-285
Helical: 286-310
Extracellular: 311-337
Helical: 338-354
Cytoplasmic: 355-363
Helical: 364-380
Extracellular: 381-386
Helical: 387-409
Cytoplasmic: 410-419
Helical: 420-443
Extracellular: 444-455
Helical: 456-479
Cytoplasmic: 480-497

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SLC19A2 (AA 209-286) Recombinant Antibody (CBXS-0432) (CAT#: CBMAB-S3382-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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