Mouse Anti-SLC20A2 Recombinant Antibody (4B1) (CBMAB-A8181-LY)

Name: Mouse Anti-SLC20A2 Recombinant Antibody (4B1)
SKU: CBMAB-A8181-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4B1

Application

WB, ELISA

Immunogen

SLC20A2 (NP_006740.1, 243 a.a. ~ 342 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

solute carrier family 20 (phosphate transporter), member 2

Entrez Gene ID

6575

UniProt ID

Q08357

Alternative Names

GLVR2; Glvr-2; MLVAR; PIT-2

Function

Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants.

Biological Process

Biological Process ion transportTAS:Reactome
Biological Process phosphate ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Basal ganglia calcification, idiopathic, 1 (IBGC1):
A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.

Topology

Extracellular: 1-5
Helical: 6-26
Cytoplasmic: 27-46
Helical: 47-67
Extracellular: 68-86
Helical: 87-107
Cytoplasmic: 108-109
Helical: 110-130
Extracellular: 131-142
Helical: 143-163
Cytoplasmic: 164-190
Helical: 191-211
Extracellular: 212-213
Helical: 214-234
Cytoplasmic: 235-482
Helical: 483-503
Extracellular: 504-530
Helical: 531-551
Cytoplasmic: 552-571
Helical: 572-586
Extracellular: 587-593
Helical: 594-609
Cytoplasmic: 610-621
Helical: 622-642
Extracellular: 643-652

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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