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Mouse Anti-SLC22A4 Recombinant Antibody (CBXS-4487) (CBMAB-S1729-CQ)

This product is a mouse antibody that recognizes SLC22A4. The antibody CBXS-4487 can be used for immunoassay techniques such as: ELISA.
See all SLC22A4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4487
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 22 (organic cation/ergothioneine transporter), member 4
Introduction
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.
Entrez Gene ID
6583
UniProt ID
Q9H015
Alternative Names
Solute Carrier Family 22 Member 4; Solute Carrier Family 22 (Organic Cation/Ergothioneine Transporter), Member 4; Solute Carrier Family 22 (Organic Cation/Zwitterion Transporter), Member 4; Organic Cation/Carnitine Transporter 1; Deafness, Autosomal Recessive 60; Ergothioneine Transporter; ET Transporter;
Function
Sodium-ion dependent transporter of various organic cationic compounds. A key substrate of this transporter is ergothioneine (ET) (PubMed:15795384).
Able to transport carnitine, probably moving one sodium ion with one molecule of carnitine. Also transports tetraethylammonium (TEA) without the involvement of sodium.
Biological Process
Biological Process amino acid import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process carnitine metabolic processIEA:Ensembl
Biological Process carnitine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process quaternary ammonium group transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transportIEA:UniProtKB-KW
Biological Process triglyceride metabolic processIEA:Ensembl
Biological Process xenobiotic transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Cellular Location
Membrane
Involvement in disease
Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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