Mouse Anti-SLC22A4 Recombinant Antibody (CBXS-4487) (CBMAB-S1729-CQ)

Name: Mouse Anti-SLC22A4 Recombinant Antibody (CBXS-4487)
SKU: CBMAB-S1729-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXS-4487

Application

ELISA

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

solute carrier family 22 (organic cation/ergothioneine transporter), member 4

Introduction

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.

Entrez Gene ID

6583

UniProt ID

Q9H015

Alternative Names

Solute Carrier Family 22 Member 4; Solute Carrier Family 22 (Organic Cation/Ergothioneine Transporter), Member 4; Solute Carrier Family 22 (Organic Cation/Zwitterion Transporter), Member 4; Organic Cation/Carnitine Transporter 1; Deafness, Autosomal Recessive 60; Ergothioneine Transporter; ET Transporter;

Function

Sodium-ion dependent transporter of various organic cationic compounds. A key substrate of this transporter is ergothioneine (ET) (PubMed:15795384).
Able to transport carnitine, probably moving one sodium ion with one molecule of carnitine. Also transports tetraethylammonium (TEA) without the involvement of sodium.

Biological Process

Biological Process amino acid import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process carnitine metabolic processIEA:Ensembl
Biological Process carnitine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process quaternary ammonium group transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transportIEA:UniProtKB-KW
Biological Process triglyceride metabolic processIEA:Ensembl
Biological Process xenobiotic transportManual Assertion Based On ExperimentIDA:ARUK-UCL

Cellular Location

Membrane

Involvement in disease

Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SLC22A4 Recombinant Antibody (2D3) (CAT#: CBMAB-A8186-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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