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Mouse Anti-SLC25A21 Recombinant Antibody (2C9) (CBMAB-A8196-LY)

The product is antibody recognizes SLC25A21. The antibody 2C9 immunoassay techniques such as: sELISA, ELISA.
See all SLC25A21 antibodies
Published Data
Fig.1 Quantification of ODC1 expression by Western blotting.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2C9
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
SLC25A21 (NP_085134.1, 36 a.a. ~ 99 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21
Introduction
SLC25A21 is a homolog of the S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, 2-oxoadipate is converted into acetyl-CoA.[supplied by OMIM
Entrez Gene ID
89874
UniProt ID
Q9BQT8
Alternative Names
MGC126570; ODC; ODC1
Function
Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism (PubMed:11083877).
Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate (PubMed:11083877).
Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle (Probable).
Biological Process
Biological Process lysine catabolic processTAS:Reactome
Biological Process mitochondrial alpha-ketoglutarate transmembrane transportManual Assertion Based On ExperimentIMP:FlyBase
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Mitochondrial DNA depletion syndrome 18 (MTDPS18):
An autosomal recessive mitochondrial disorder characterized by early-onset progressive weakness and atrophy of the distal limb muscles, loss of ambulation, and atrophy of the intrinsic hand muscles with clawed hands. Additional features include scoliosis, hypo- or hyperreflexia, and decreased pulmonary vital capacity. Examination of skeletal muscle shows mitochondrial respiratory chain deficiencies involving complexes I and IV, associated with mtDNA depletion.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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