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Mouse Anti-SLC25A6 Recombinant Antibody (CBXS-4364) (CBMAB-S1608-CQ)

This product is a mouse antibody that recognizes SLC25A6. The antibody CBXS-4364 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC25A6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4364
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Introduction
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. The human genome contains several non-transcribed pseudogenes of this gene.
Entrez Gene ID
UniProt ID
Alternative Names
Solute Carrier Family 25 Member 6; Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6; Adenine Nucleotide Translocator 3; ADP,ATP Carrier Protein 3; ANT 2; ANT 3; ANT3; ADP,ATP Carrier Protein, Isoform T2;
Function
ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity).
Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity).
In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708).
Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity).
Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity).
Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity).
Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708).
It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity).
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process mitochondrial ADP transmembrane transportIEA:InterPro
Biological Process mitochondrial ATP transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion inner membrane
Membrane
The complex formed with ARL2BP, ARL2 and SLC25A6/ANT3 is expressed in mitochondria (By similarity).
May localize to non-mitochondrial membranes (By similarity).
Topology
Mitochondrial intermembrane: 1-7
Helical: 8-37
Mitochondrial matrix: 38-74
Helical: 75-99
Mitochondrial intermembrane: 100-109
Helical: 110-130
Mitochondrial matrix: 131-178
Helical: 179-199
Mitochondrial intermembrane: 200-210
Helical: 211-231
Mitochondrial matrix: 232-273
Helical: 274-291
Mitochondrial intermembrane: 292-298
PTM
Trimethylated by ANTKMT at Lys-52.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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