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Mouse Anti-SLC26A2 Recombinant Antibody (3F6) (CBMAB-A8202-LY)

The product is antibody recognizes SLC26A2. The antibody 3F6 immunoassay techniques such as: WB, ELISA.
See all SLC26A2 antibodies
Published Data
Fig. 1 Western blot
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F6
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
SLC26A2 (NP_000103.1, 1 a.a. ~ 108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 26 (sulfate transporter), member 2
Introduction
The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq]
Entrez Gene ID
1836
UniProt ID
P50443
Alternative Names
D5S1708; DTD; DTDST; EDM4; MST153; MSTP157
Function
Sulfate transporter. May play a role in endochondral bone formation.
Biological Process
Biological Process 3'-phosphoadenosine 5'-phosphosulfate biosynthetic processTAS:Reactome
Biological Process ion transportTAS:Reactome
Biological Process ossificationIEA:Ensembl
Biological Process sulfate transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Diastrophic dysplasia (DTD):
An autosomal recessive disease characterized by osteochondrodysplasia with clinical features including dwarfism, spinal deformation, and specific joint abnormalities.
Achondrogenesis 1B (ACG1B):
A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. ACG1B is an autosomal recessive disease.
Atelosteogenesis 2 (AO2):
A perinatal dysplasia characterized by shortening of the limbs, a dysmorphic syndrome and radiographic skeletal features. Patients are stillborn or die soon after birth.
Multiple epiphyseal dysplasia 4 (EDM4):
A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. Multiple epiphyseal dysplasia type 4 is a recessively inherited form, characterized by early childhood-onset hip dysplasia and recurrent patella dislocation. Short stature is not frequent.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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