Mouse Anti-SLC29A4 Recombinant Antibody (6B6) (CBMAB-A8213-LY)

Name: Mouse Anti-SLC29A4 Recombinant Antibody (6B6)
SKU: CBMAB-A8213-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

6B6

Application

WB, ELISA

Immunogen

SLC29A4 (NP_694979, 283 a.a. ~ 345 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human, Rat

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

solute carrier family 29 (nucleoside transporters), member 4

Introduction

This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized. [provided by RefSeq]

Entrez Gene ID

Human	222962
Rat	288499

UniProt ID

Human	Q7RTT9
Rat	F1M2Y4

Alternative Names

ENT4; FLJ34923; PMAT

Function

Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorption. Does not seem to transport nucleoside and nucleoside analogs such as uridine, cytidine, thymidine, adenosine, inosine, guanosine, and azidothymidine. In (PubMed:16873718) adenosine is efficiently transported but in a fashion highly sensitive to extracellular pH, with maximal activity in the pH range 5.5 to 6.5. Glu-206 is essential for the cation selectivity and may function as the charge sensor for cationic substrates. Transport is chloride and sodium-independent but appears to be sensitive to changes in membrane potential. Weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine. May play a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia.

Biological Process

Biological Process cation transmembrane transportISS:ARUK-UCL
Biological Process dopamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process epinephrine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process export across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process histamine metabolic processManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process histamine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process monoamine transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process neurotransmitter transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process norepinephrine uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process organic acid transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process organic cation transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process toxin transportISS:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Biological Process xenobiotic transportManual Assertion Based On ExperimentIDA:ARUK-UCL

Cellular Location

Cell membrane
Apical cell membrane
Located to the plasma membranes of ventricular myocytes and vascular endothelial cells. Targeted to the apical membranes of differentiated kidney epithelial cells.

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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