Mouse Anti-SLC2A10 Recombinant Antibody (CBXS-2759) (CBMAB-S5510-CQ)

solute carrier family 2 (facilitated glucose transporter), member 10

This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.

Solute Carrier Family 2 Member 10; Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 10; Glucose Transporter Type 10; GLUT-10; GLUT10; Solute Carrier Family 2, Facilitated Glucose Transporter Member 10; ATS;

Facilitative glucose transporter required for the development of the cardiovascular system.

Biological Process artery developmentManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process cell redox homeostasisManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process circulatory system developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process dehydroascorbic acid transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process embryonic skeletal joint developmentManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process galactose transmembrane transportManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process glucose import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process glucose transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process hexose transmembrane transportTAS:Reactome
Biological Process negative regulation of connective tissue growth factor productionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of proteoglycan biosynthetic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of SMAD protein signal transductionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of gene expressionManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of proteoglycan biosynthetic processManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process positive regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process regulation of extracellular matrix organizationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process skin developmentManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Endomembrane system
Cytoplasm, perinuclear region

Arterial tortuosity syndrome (ATORS):
An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries.