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Mouse Anti-SLC33A1 Recombinant Antibody (CBXS-3003) (CBMAB-S5749-CQ)

This product is a mouse antibody that recognizes SLC33A1. The antibody CBXS-3003 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC33A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBXS-3003
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-70 from SLC33A1 (NP_004724) with GST tag
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 33 (acetyl-CoA transporter), member 1
Introduction
The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene.
Entrez Gene ID
Human9197
Rat64018
UniProt ID
HumanO00400
RatQ6AYY8
Alternative Names
Solute Carrier Family 33 Member 1; Solute Carrier Family 33 (Acetyl-CoA Transporter), Member 1; ACATN; AT-1; AT1; Spastic Paraplegia 42 (Autosomal Dominant);
Function
Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:9096318).
Negatively regulates BMP signaling (PubMed:25402622).
Biological Process
Transmembrane transportTAS:Reactome
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Spastic paraplegia 42, autosomal dominant (SPG42):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Congenital cataracts, hearing loss, and neurodegeneration (CCHLND):
An autosomal recessive disorder characterized by congenital cataracts, severe psychomotor retardation, and hearing loss associated with decreased serum ceruloplasmin and copper. Brain MRI shows cerebral and cerebellar atrophy and hypomyelination.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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