Rabbit Anti-SLC34A3 Recombinant Antibody (CBXS-1642) (CBMAB-S4491-CQ)

Name: Rabbit Anti-SLC34A3 Recombinant Antibody (CBXS-1642)
SKU: CBMAB-S4491-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBXS-1642

Application

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 34 Member 3

Introduction

This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.

Entrez Gene ID

Human	142680
Mouse	142681
Rat	246234

UniProt ID

Human	Q8N130
Mouse	Q80SU6
Rat	Q8K4R8

Alternative Names

Solute Carrier Family 34 Member 3; Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 3; Solute Carrier Family 34 (Sodium Phosphate), Member 3; Sodium/Inorganic Phosphate Cotransporter IIC; Na(+)-Dependent Phosphate Cotransporter 2C; Sodium-Phosphate Transport Protein 2C; Na(+)/Pi Cotransporter 2C; NaPi-2c;

Function

Involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane (PubMed:11880379).
The cotransport has a Na+:Pi stoichiometry of 2:1 and is electroneutral (By similarity).

Biological Process

Biological Process cellular phosphate ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphate ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium-dependent phosphate transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Apical cell membrane
ocalized at the brush border membrane in the kidney.

Involvement in disease

Hereditary hypophosphatemic rickets with hypercalciuria (HHRH):
Autosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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