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Rabbit Anti-SLC34A3 Recombinant Antibody (CBXS-1642) (CBMAB-S4491-CQ)

This product is a rabbit antibody that recognizes SLC34A3. The antibody CBXS-1642 can be used for immunoassay techniques such as: WB.
See all SLC34A3 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1642
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 34 Member 3
Introduction
This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.
Entrez Gene ID
Human142680
Mouse142681
Rat246234
UniProt ID
HumanQ8N130
MouseQ80SU6
RatQ8K4R8
Alternative Names
Solute Carrier Family 34 Member 3; Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 3; Solute Carrier Family 34 (Sodium Phosphate), Member 3; Sodium/Inorganic Phosphate Cotransporter IIC; Na(+)-Dependent Phosphate Cotransporter 2C; Sodium-Phosphate Transport Protein 2C; Na(+)/Pi Cotransporter 2C; NaPi-2c;
Function
Involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane (PubMed:11880379).
The cotransport has a Na+:Pi stoichiometry of 2:1 and is electroneutral (By similarity).
Biological Process
Biological Process cellular phosphate ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process phosphate ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium-dependent phosphate transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Apical cell membrane
ocalized at the brush border membrane in the kidney.
Involvement in disease
Hereditary hypophosphatemic rickets with hypercalciuria (HHRH):
Autosomal recessive form of hypophosphatemia characterized by reduced renal phosphate reabsorption and rickets. Increased serum levels of 1,25-dihydroxyvitamin D lead to increase in urinary calcium excretion.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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