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Mouse Anti-SLC36A2 Recombinant Antibody (CBXS-2961) (CBMAB-S5709-CQ)

This product is a mouse antibody that recognizes SLC36A2. The antibody CBXS-2961 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC36A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2961
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa1-72 from human SLC36A2 (NP_861441) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 36 (proton/amino acid symporter), member 2
Introduction
This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria.
Entrez Gene ID
UniProt ID
Alternative Names
Solute Carrier Family 36 Member 2; Solute Carrier Family 36 (Proton/Amino Acid Symporter), Member 2; Tramdorin-1; TRAMD1; PAT2; Proton-Coupled Amino Acid Transporter 2; Proton/Amino Acid Transporter 2;
Function
Electrogenic proton/amino acid symporter with a high selectivity for the small side chains amino acids glycine, alanine and proline, where both L- and D-enantiomers are transported. Extension of the backbone length, as in beta-alanine and 4-aminobutanoate or methylation of the amino group, as in sarcosine and N,N-dimethylglycine, are also tolerated but decrease transport efficiency. A free carboxyl group is preferred.
Biological Process
Biological Process amino acid transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process amino acid transportTAS:Reactome
Biological Process glycine transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ion transportTAS:Reactome
Biological Process L-alanine transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process proline transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process proline transportIEA:Ensembl
Biological Process proton transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Endoplasmic reticulum membrane
Recycling endosome membrane
Involvement in disease
Hyperglycinuria (HG):
A condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones.
Iminoglycinuria (IG):
A disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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