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Mouse Anti-SLC38A3 Recombinant Antibody (CBXS-2279) (CBMAB-S5041-CQ)

This product is a mouse antibody that recognizes SLC38A3. The antibody CBXS-2279 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SLC38A3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2279
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 38 Member 3
Entrez Gene ID
Human10991
Mouse76257
Rat252919
UniProt ID
HumanQ99624
MouseQ9DCP2
RatQ9JHZ9
Alternative Names
Solute Carrier Family 38 Member 3; Na(+)-Coupled Neutral Amino Acid Transporter 3; System N Amino Acid Transporter 1; N-System Amino Acid Transporter 1; SNAT3; NAT1;
Function
Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H+ antiporter activity (PubMed:10823827).
Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (By similarity).
The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10823827).
The transport is electroneutral coupled to the cotransport of 1 Na+ and the antiport of 1 H+ (By similarity).
The transport is pH dependent, saturable, Li+ tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10823827).
Also mediates an amino acid-gated H+ conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity).
In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (By similarity).
Biological Process
Biological Process amino acid homeostasisISS:UniProtKB
Biological Process amino acid transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process amino acid transportTAS:Reactome
Biological Process asparagine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process brain developmentIEA:Ensembl
Biological Process cellular response to potassium ion starvationIEA:Ensembl
Biological Process female pregnancyIEA:Ensembl
Biological Process glutamine secretionISS:UniProtKB
Biological Process glutamine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process histidine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-alanine transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process L-asparagine import across plasma membraneISS:UniProtKB
Biological Process L-glutamine import across plasma membraneISS:UniProtKB
Biological Process L-histidine import across plasma membraneISS:UniProtKB
Biological Process L-histidine transportISS:UniProtKB
Biological Process positive regulation of glutamine transportIEA:Ensembl
Biological Process positive regulation of transcription from RNA polymerase II promoter in response to acidic pHIEA:Ensembl
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Cellular Location
Cell membrane
Basolateral cell membrane
The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein. Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells. In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling. Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (By similarity).
Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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