Mouse Anti-SLC40A1 Recombinant Antibody (CBXF-2429) (CBMAB-F1977-CQ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity).
Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity).
When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).
Biological Process cellular iron ion homeostasisManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process endothelium developmentIEA:Ensembl
Biological Process establishment of localization in cellIEA:Ensembl
Biological Process iron ion export across plasma membraneISS:ARUK-UCL
Biological Process iron ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process iron ion transmembrane transportManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process lymphocyte homeostasisIEA:Ensembl
Biological Process multicellular organismal iron ion homeostasisISS:BHF-UCL
Biological Process negative regulation of apoptotic processIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process regulation of transcription from RNA polymerase II promoter in response to ironIEA:Ensembl
Biological Process spleen trabecula formationIEA:Ensembl
Biological Process transcription by RNA polymerase IIIEA:Ensembl
Localized to the basolateral membrane of polarized epithelial cells.
A disorder of iron metabolism characterized by iron overload. Excess iron is deposited in a variety of organs leading to their failure, and resulting in serious illnesses including cirrhosis, hepatomas, diabetes, cardiomyopathy, arthritis, and hypogonadotropic hypogonadism. Severe effects of the disease usually do not appear until after decades of progressive iron loading.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Mouse Slc40a1 ELISA Kit (CAT#: V2LY-0626-LY3078)
Mouse Anti-SLC40A1 Monoclonal Antibody (Y33C) (CAT#: CBMAB-1243-YC)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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