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Mouse Anti-SLC4A4 Recombinant Antibody (1G2) (CBMAB-A8246-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G2
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SLC4A4 (AAH30977, 1 a.a. ~ 646 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 4, sodium bicarbonate cotransporter, member 4
Introduction
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
8671
UniProt ID
Q9Y6R1
Alternative Names
DKFZp781H1314; HNBC1; KNBC; NBC1; NBC2; SLC4A5; hhNMC; pNBC
Function
Electrogenic sodium/bicarbonate cotransporter with a Na+:HCO3- stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Biological Process
Biological Process bicarbonate transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of glycolytic processManual Assertion Based On ExperimentIGI:ARUK-UCL
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process regulation of membrane potentialManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion export across plasma membraneManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Basolateral cell membrane
Cell membrane
Involvement in disease
Renal tubular acidosis, proximal, with ocular abnormalities and intellectual disability (pRTA-OA):
An extremely rare autosomal recessive syndrome characterized by short stature, profound proximal renal tubular acidosis, intellectual disability, bilateral glaucoma, cataracts and bandkeratopathy. pRTA is due to a failure of the proximal tubular cells to reabsorb filtered bicarbonate from the urine, leading to urinary bicarbonate wasting and subsequent acidemia.
PTM
Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na+:HCO3- stoichiometry of the transporter from 3:1 to 2:1 (PubMed:11744745, PubMed:12411514, PubMed:12730338).
Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity (By similarity).
N-glycosylated. May not be necessary for the transporter basic functions.
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For research use only. Not intended for any clinical use.

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