Mouse Anti-SLC5A2 Recombinant Antibody (3G8) (CBMAB-A8249-LY)

Name: Mouse Anti-SLC5A2 Recombinant Antibody (3G8)
SKU: CBMAB-A8249-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3G8

Application

WB, ELISA

Immunogen

SLC5A2 (NP_003032.1, 228 a.a. ~ 277 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

solute carrier family 5 (sodium/glucose cotransporter), member 2

Introduction

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. [provided by RefSeq]

Entrez Gene ID

6524

UniProt ID

P31639

Alternative Names

SGLT2

Function

Electrogenic Na+-coupled sugar simporter that actively transports D-glucose at the plasma membrane, with a Na+ to sugar coupling ratio of 1:1. Transporter activity is driven by a transmembrane Na+ electrochemical gradient set by the Na+/K+ pump (PubMed:20980548, PubMed:28592437, PubMed:34880493).
Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).

Biological Process

Biological Process alpha-glucoside transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process carbohydrate metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process glucose import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process hexose transmembrane transportTAS:Reactome
Biological Process renal glucose absorptionISS:UniProtKB
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Apical cell membrane

Involvement in disease

Renal glucosuria (GLYS):
A disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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