Mouse Anti-SLC5A6 Recombinant Antibody (CBXS-2116) (CBMAB-S4881-CQ)

Name: Mouse Anti-SLC5A6 Recombinant Antibody (CBXS-2116)
SKU: CBMAB-S4881-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-2116

Application

WB, IP, IF, ELISA

Specificity

Human

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 5 Member 6

Entrez Gene ID

8884

UniProt ID

Q9Y289

Alternative Names

Solute Carrier Family 5 Member 6; Solute Carrier Family 5 (Sodium/Multivitamin And Iodide Cotransporter), Member 6; Solute Carrier Family 5 (Sodium-Dependent Vitamin Transporter), Member 6; Na(+)-Dependent Multivitamin Transporter; SMVT; Sodium-Dependent Multivitamin Transporter; Na+-Dependent Multivitamin Transporter;

Function

Sodium-dependent multivitamin transporter that transports pantothenate, biotin and lipoate (PubMed:10329687, PubMed:15561972, PubMed:21570947, PubMed:20980265, PubMed:22927035, PubMed:22015582, PubMed:25971966, PubMed:25809983, PubMed:28052864, PubMed:27904971, PubMed:31754459).
Required for biotin and pantothenate uptake in the instestine (By similarity).
Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity).
May play a role in the transport of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983).
May also be involved in the sodium-dependent transport of iodide ions (PubMed:20980265).

Biological Process

Biological Process biotin import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process biotin transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process iodide transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process pantothenate transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrierManual Assertion Based On ExperimentIMP:ARUK-UCL

Cellular Location

Cell membrane
(Microbial infection) Exposure to E.coli lipopolysaccharides leeds to reduced cell membrane localization.

Involvement in disease

Neurodegeneration, infantile-onset, biotin-responsive (NERIB):
An autosomal recessive disorder characterized by early infantile onset, progressive neurodegeneration, global developmental delay, and developmental regression with loss of early motor and cognitive milestones. Additional variable features include seizures, ataxia, spasticity, peripheral neuropathy, immune defects, and osteopenia. Treatment with biotin, pantothenic acid, and lipoate may result in clinical improvement.

PTM

May be glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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