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Mouse Anti-SLC5A6 Recombinant Antibody (CBXS-2116) (CBMAB-S4881-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2116
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 5 Member 6
Entrez Gene ID
8884
UniProt ID
Q9Y289
Alternative Names
Solute Carrier Family 5 Member 6; Solute Carrier Family 5 (Sodium/Multivitamin And Iodide Cotransporter), Member 6; Solute Carrier Family 5 (Sodium-Dependent Vitamin Transporter), Member 6; Na(+)-Dependent Multivitamin Transporter; SMVT; Sodium-Dependent Multivitamin Transporter; Na+-Dependent Multivitamin Transporter;
Function
Sodium-dependent multivitamin transporter that transports pantothenate, biotin and lipoate (PubMed:10329687, PubMed:15561972, PubMed:21570947, PubMed:20980265, PubMed:22927035, PubMed:22015582, PubMed:25971966, PubMed:25809983, PubMed:28052864, PubMed:27904971, PubMed:31754459).
Required for biotin and pantothenate uptake in the instestine (By similarity).
Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity).
May play a role in the transport of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983).
May also be involved in the sodium-dependent transport of iodide ions (PubMed:20980265).
Biological Process
Biological Process biotin import across plasma membraneManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process biotin transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process iodide transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process pantothenate transmembrane transportManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrierManual Assertion Based On ExperimentIMP:ARUK-UCL
Cellular Location
Cell membrane
(Microbial infection) Exposure to E.coli lipopolysaccharides leeds to reduced cell membrane localization.
Involvement in disease
Neurodegeneration, infantile-onset, biotin-responsive (NERIB):
An autosomal recessive disorder characterized by early infantile onset, progressive neurodegeneration, global developmental delay, and developmental regression with loss of early motor and cognitive milestones. Additional variable features include seizures, ataxia, spasticity, peripheral neuropathy, immune defects, and osteopenia. Treatment with biotin, pantothenic acid, and lipoate may result in clinical improvement.
PTM
May be glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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