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Mouse Anti-SLC5A8 Recombinant Antibody (CBXS-1972) (CBMAB-S0152-CQ)

This product is a mouse antibody that recognizes SLC5A8. The antibody CBXS-1972 can be used for immunoassay techniques such as: FC.
See all SLC5A8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1972
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human SLC5A8/SMCT1, Met1-Leu610, Accession # NP_666018
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
A saline solution, BSA
Preservative
Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 5 Member 8
Introduction
SLC5A8 has been shown to transport iodide by a passive mechanism (Rodriguez et al., 2002 [PubMed 12107270]) and monocarboxylates and short-chain fatty acids by a sodium-coupled mechanism (Gopal et al., 2004 [PubMed 15322102]). In kidney, SLC5A8 functions as a high-affinity sodium-coupled lactate transporter involved in reabsorption of lactate and maintenance of blood lactate levels (Thangaraju et al., 2006 [PubMed 16873376]).
Entrez Gene ID
160728
UniProt ID
Q8N695
Alternative Names
Solute Carrier Family 5 Member 8; Solute Carrier Family 5 (Sodium/Monocarboxylate Cotransporter), Member 8; Solute Carrier Family 5 (Iodide Transporter), Member 8; Electrogenic Sodium Monocarboxylate Cotransporter; Sodium Iodide-Related Cotransporter; Apical Iodide Transporter;
Function
Acts as an electrogenic sodium (Na+) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na+:substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na+ gradient and hence contribute to the maintenance of the energy status and function of neurons.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process ion transportTAS:Reactome
Biological Process NAD biosynthesis via nicotinamide riboside salvage pathwayTAS:Reactome
Biological Process propanoate transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Apical cell membrane
Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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