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Rabbit Anti-SLC6A1 Recombinant Antibody (BA0122) (CBMAB-0852CQ)

This product is a rabbit antibody that recognizes SLC6A1. The antibody BA0122 can be used for immunoassay techniques such as: WB.
See all SLC6A1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0122
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Human GABA Transporter 1 aa 150-250
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
Introduction
The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft.Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
Entrez Gene ID
Human6529
Mouse232333
Rat79212
UniProt ID
HumanP30531
MouseP31648
RatP23978
Alternative Names
MAE; GAT1; GABATR; GABATHG
Function
Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:30132828).
The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity).
The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na+, Cl- and GABA (By similarity).
Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity).
Biological Process
Biological Process associative learningISS:ARUK-UCL
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process chloride transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process gamma-aminobutyric acid importManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process gamma-aminobutyric acid reuptakeTAS:Reactome
Biological Process inorganic anion import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process memoryISS:ARUK-UCL
Biological Process negative regulation of synaptic transmission, GABAergicIEA:Ensembl
Biological Process positive regulation of gamma-aminobutyric acid secretionIEA:Ensembl
Biological Process response to calcium ionIEA:Ensembl
Biological Process response to cocaineIEA:Ensembl
Biological Process response to estradiolIEA:Ensembl
Biological Process response to inorganic substanceManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process response to lead ionIEA:Ensembl
Biological Process response to purine-containing compoundIEA:Ensembl
Biological Process response to sucroseIEA:Ensembl
Biological Process response to toxic substanceIEA:Ensembl
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synapse organizationISS:ARUK-UCL
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Cell membrane
Presynapse
Localized at the presynaptic terminals of interneurons.
Involvement in disease
Myoclonic-atonic epilepsy (MAE):
A form of epilepsy characterized by myoclonic-atonic and absence seizures, appearing in early childhood. Patients have delayed development before the onset of seizures and show varying degrees of intellectual disability following seizure onset.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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