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Mouse Anti-SLC6A19 Recombinant Antibody (CBXS-5059) (CBMAB-S2280-CQ)

This product is a mouse antibody that recognizes SLC6A19. The antibody CBXS-5059 can be used for immunoassay techniques such as: WB, IP, ELISA.
See all SLC6A19 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5059
Antibody Isotype
IgG2a, κ
Application
WB, IP, ELISA

Basic Information

Immunogen
Partial recombinant protein corresponding to aa326-415 from human SLC6A19 (NP_001003841) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 6 (neutral amino acid transporter), member 19
Introduction
This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder.
Entrez Gene ID
340024
UniProt ID
Q695T7
Alternative Names
Solute Carrier Family 6 Member 19; Solute Carrier Family 6 (Neutral Amino Acid Transporter), Member 19; System B(0) Neutral Amino Acid Transporter AT1; B0AT1; Solute Carrier Family 6 (Neurotransmitter Transporter), Member 19; Sodium-Dependent Neutral Amino Acid Transporter B(0)AT1;
Function
Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:15286787, PubMed:15286788, PubMed:18424768, PubMed:18484095, PubMed:19185582, PubMed:26240152).
This uptake is sodium-dependent and chloride-independent (PubMed:15286787, PubMed:19185582, PubMed:15286788).
Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:19185582, PubMed:18424768).
Biological Process
Biological Process amino acid transportTAS:Reactome
Biological Process response to nutrientIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process viral life cycle1 PublicationIC:ComplexPortal
Cellular Location
Cell membrane
Apical cell membrane
Colocalizes with ACE2 on the apical membrane of cells lining villi of the jejunum, ileum and on kidney proximal tubules.
Involvement in disease
Hartnup disorder (HND):
Autosomal recessive abnormality of renal and gastrointestinal neutral amino acid transport noted for its clinical variability. First described in 1956, HND is characterized by increases in the urinary and intestinal excretion of neutral amino acids. Individuals with typical Hartnup aminoaciduria may be asymptomatic, some develop a photosensitive pellagra-like rash, attacks of cerebellar ataxia and other neurological or psychiatric features. Although the definition of HND was originally based on clinical and biochemical abnormalities, its marked clinical heterogeneity has led to it being known as a disorder with a consistent pathognomonic neutral hyperaminoaciduria.
Hyperglycinuria (HG):
A condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones.
Iminoglycinuria (IG):
A disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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