Mouse Anti-SLC6A4 Recombinant Antibody (CBXS-0493) (CBMAB-S3442-CQ)

solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.

5-HTT; AI323329; Htt; Sert

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Biological Process brain morphogenesisISS:BHF-UCL
Biological Process cellular response to cGMPIEA:Ensembl
Biological Process cellular response to retinoic acidIEA:Ensembl
Biological Process circadian rhythmIEA:Ensembl
Biological Process memoryIEA:Ensembl
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process negative regulation of cerebellar granule cell precursor proliferationIEA:Ensembl
Biological Process negative regulation of neuron differentiationIEA:Ensembl
Biological Process negative regulation of organ growthISS:BHF-UCL
Biological Process negative regulation of synaptic transmission, dopaminergicIEA:Ensembl
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process positive regulation of cell cycleIEA:Ensembl
Biological Process positive regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of serotonin secretionIEA:Ensembl
Biological Process regulation of thalamus sizeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process response to estradiolIEA:Ensembl
Biological Process response to hypoxiaIEA:Ensembl
Biological Process response to nutrientIEA:Ensembl
Biological Process response to toxic substanceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process serotonin uptakeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process social behaviorISS:BHF-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sperm ejaculationIEA:Ensembl
Biological Process vasoconstrictionIEA:Ensembl

Cell membrane
Endomembrane system
Endosome membrane
Synapse
Cell junction, focal adhesion
Could be part of recycling endosomes (PubMed:16870614).
Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity).
Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858).
Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity).

Phosphorylation at Thr-276 increases 5-HT uptake and is required for cGMP-mediated SERT regulation.