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Mouse Anti-SLC7A7 Recombinant Antibody (CBXS-3015) (CBMAB-S5761-CQ)

This product is a mouse antibody that recognizes SLC7A7. The antibody CBXS-3015 can be used for immunoassay techniques such as: ELISA.
See all SLC7A7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3015
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa462-512 from LC7A7 (NP_003973) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 7 (cationic amino acid transporter, y+ system), member 7
Introduction
The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants.
Entrez Gene ID
9056
UniProt ID
Q9UM01
Alternative Names
Solute Carrier Family 7 Member 7; Solute Carrier Family 7 (Amino Acid Transporter Light Chain, Y+L System), Member 7; Y(+)L-Type Amino Acid Transporter 1; Monocyte Amino Acid Permease 2; Y+LAT-1; Y+LAT1;
Function
Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes.
Biological Process
Biological Process basic amino acid transmembrane transportManual Assertion Based On ExperimentTAS:GO_Central
Biological Process regulation of arginine metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Basolateral cell membrane
Involvement in disease
Lysinuric protein intolerance (LPI):
A metabolic disorder characterized by increased renal excretion of cationic amino acid (CAA), reduced CAA absorption from intestine, and orotic aciduria. On a normal diet, LPI patients present poor feeding, vomiting, diarrhea, episodes of hyperammoniaemic coma and growth retardation. Hepatosplenomegaly, osteoporosis and a life-threatening pulmonary involvement (alveolar proteinosis) are also seen. Biochemically LPI is characterized by defective transport of dibasic amino acids at the basolateral membrane of epithelial cells in kidney and intestine.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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