Mouse Anti-SLCO1B3 Recombinant Antibody (CBXO-0509) (CBMAB-O0027-CQ)

Name: Mouse Anti-SLCO1B3 Recombinant Antibody (CBXO-0509)
SKU: CBMAB-O0027-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXO-0509

Application

FC, IHC, IHC-P

Specificity

Human

Antibody Isotype

IgG3, Κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Organic Anion Transporter Family Member 1B3

Introduction

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. Alternative splicing of this gene and the use of alternative promoters results in transcript variants encoding different isoforms that differ in their tissue specificity.

Entrez Gene ID

28234

UniProt ID

Q9NPD5

Alternative Names

Solute Carrier Organic Anion Transporter Family Member 1B3; Solute Carrier Family 21 (Organic Anion Transporter), Member 8; Liver-Specific Organic Anion Transporter 2; Organic Anion-Transporting Polypeptide 8; Organic Anion Transporter 8; SLC21A8; OATP1B3; OATP-8; LST-2; OATP8

Function

Mediates the Na+-independent uptake of organic anions (PubMed:15159445, PubMed:17412826, PubMed:10779507).
Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate), as well as eicosanoid leukotriene C4 (PubMed:15159445, PubMed:17412826, PubMed:10779507, PubMed:12568656).
Involved in the clearance of bile acids and organic anions from the liver (PubMed:22232210).
Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210).
Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:15159445).
May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220).
May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16627748, PubMed:16624871).

Biological Process

Biological Process bile acid and bile salt transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process heme catabolic processTAS:Reactome
Biological Process organic anion transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process sodium-independent organic anion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process xenobiotic metabolic processTAS:Reactome

Cellular Location

Basolateral cell membrane

Involvement in disease

Hyperbilirubinemia, Rotor type (HBLRR):
An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal.

PTM

N-glycosylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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