Sign in or Register   Sign in or Register
  |  

Mouse Anti-SLCO1C1 Recombinant Antibody (CBXO-0347) (CBMAB-O0220-CQ)

This product is a mouse antibody that recognizes SLCO1C1. The antibody CBXO-0347 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SLCO1C1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXO-0347
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Organic Anion Transporter Family Member 1C1
Introduction
This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human53919
Mouse58807
Rat84511
UniProt ID
HumanQ9NYB5
MouseQ9ERB5
RatQ9EPZ7
Alternative Names
Solute Carrier Organic Anion Transporter Family Member 1C1; Solute Carrier Family 21 (Organic Anion Transporter), Member 14; Organic Anion Transporter Polypeptide-Related Protein 5; Solute Carrier Family 21 Member 14; Organic Anion Transporter F; Thyroxine Transporter; SLC21A14; OAT-RP-5; OATP-14; OATP1C1
Function
Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain (By similarity).
Biological Process
Biological Process bile acid and bile salt transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of thyroid hormone generationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process sodium-independent organic anion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thyroid hormone transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL
Cellular Location
Cell membrane
Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity).
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SLCO1C1 Recombinant Antibody (CBXO-0347)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare