Mouse Anti-SLCO1C1 Recombinant Antibody (CBXO-0347) (CBMAB-O0220-CQ)

Name: Mouse Anti-SLCO1C1 Recombinant Antibody (CBXO-0347)
SKU: CBMAB-O0220-CQ
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Mouse

Clone

CBXO-0347

Application

WB, IP, IF, ELISA

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Organic Anion Transporter Family Member 1C1

Introduction

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

Human	53919
Mouse	58807
Rat	84511

UniProt ID

Human	Q9NYB5
Mouse	Q9ERB5
Rat	Q9EPZ7

Alternative Names

Solute Carrier Organic Anion Transporter Family Member 1C1; Solute Carrier Family 21 (Organic Anion Transporter), Member 14; Organic Anion Transporter Polypeptide-Related Protein 5; Solute Carrier Family 21 Member 14; Organic Anion Transporter F; Thyroxine Transporter; SLC21A14; OAT-RP-5; OATP-14; OATP1C1

Function

Mediates the Na+-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a significant role in regulating T4 flux into and out of the brain (By similarity).

Biological Process

Biological Process bile acid and bile salt transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of thyroid hormone generationManual Assertion Based On ExperimentIMP:ARUK-UCL
Biological Process sodium-independent organic anion transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process thyroid hormone transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transport across blood-brain barrier2 PublicationsNAS:ARUK-UCL

Cellular Location

Cell membrane
Expressed in both luminal and abluminal membranes of brain capillary endothelial cells. Localized to the apical membrane and basal surfaces of choroid plexus (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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