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Mouse Anti-SLFN11 Recombinant Antibody (CBXS-2133) (CBMAB-S4897-CQ)

This product is a mouse antibody that recognizes SLFN11. The antibody CBXS-2133 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SLFN11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2133
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Schlafen Family Member 11
Entrez Gene ID
91607
UniProt ID
Q7Z7L1
Alternative Names
Schlafen Family Member 11; SLFN8/9;
Function
Inhibitor of DNA replication that promotes cell death in response to DNA damage (PubMed:22927417, PubMed:26658330, PubMed:29395061).
Acts as a guardian of the genome by killing cells with defective replication (PubMed:29395061).
Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death (PubMed:29395061).
Acts independently of ATR (PubMed:29395061).
Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis (PubMed:23000900).
Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner (PubMed:23000900).
Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides (PubMed:23000900).
The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation (PubMed:23000900).
Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA (PubMed:23000900).
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to virusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process immune system processIEA:UniProtKB-KW
Biological Process negative regulation of DNA replicationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of G1/S transition of mitotic cell cycleManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of cell deathManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process replication fork arrestManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Chromosome
Recruited to stressed replication forks carrying extended RPA filaments (PubMed:29395061).
Recruited to DNA damage sites via interaction with RPA1 (PubMed:26658330, PubMed:29395061).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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