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Mouse Anti-SMAD2 Monoclonal Antibody (1B4) (CBMAB-0114-LY)

This product is mouse monoclonal antibody recognizes SMAD2 of human. The antibody 1B4 immunoassay techniques such as: IP, MA.
Host Species
Mouse
Application
IP, MA
Immunogen
Recombinant peptide (Full Length)
Antibody Isotype
IgG2b
Specificity
Human
Clone
1B4
Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
The protein encoded by this gene belongs to the SMAD. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on the formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma.
Alternative Name
JV18-1; MADH2; MADR2
Entrez Gene ID
UniProt ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-0114-LY
Conjugates
Size
Price $
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Second antibody and isotype control